“…a fresh argument for the productive value of inequality.” - David Autor, Professor of Economics, Massachusetts Institute of Technology
“Unintended Consequences is far smarter and more thought-provoking than most economics written for the general public” - Greg Mankiw, Harvard University, Former Chairman of the Council of Economic Advisors
“Unintended Consequences represents the most cogent and persuasive analysis of the Financial Crisis to date.” - Andrei Shleifer, 1999 John Bates Clark Medal Winner
“A full-throated defense of economic dynamism.” - The Wall Street Journal
“…challenges misconceptions that distort our economic debates.” - Arthur Brooks, President of the American Enterprise Institute
“…reminds us that inequality sends a signal of what society lacks most, in America’s case, entrepreneurship and risk taking.” - Lawrence Lindsey, CEO, The Lindsey Group, former Director of the National Economic Council
“…serious thinking for serious thinkers. …a thought-provoking blueprint for growing middle- and working-class incomes.” - Mitt Romney, former Governor of Massachusetts
“…a must-read for serious students of economic policy.” - Glenn Hubbard, Dean, Columbia Business School, and former Chairman of the Council of Economic Advisers
“Unintended Consequences is full of substance, it is one of the must-read books of the year, and once I finish it I will be giving it a second read through right away.” - Tyler Cowen, Professor, George Mason University
“…a very valuable contribution.” - Larry Summers, former Secretary of the Treasury and director of the National Economic Council, president emeritus, Harvard University
“…a comprehensive explanation of the modern economy.” - Julian Robertson, Founder, Tiger Management
“…a very valuable contribution.” - Larry Summers, former Secretary of the Treasury and director of the National Economic Council, president emeritus, Harvard University

For whatever topics you select (currently: Science):

Include articles that mention this topic 113

Only articles primarily about this topic 11

Influence of a Large Language Model on Diagnostic Reasoning: A Randomized Clinical Vignette Study

Ethan Goh, MD, MS, Robert Gallo, MD, Jason Hom, MD, et al. medRxiv

Date Posted:: October 3, 2024

In a trial with 50 physicians to test the impact of GPT-4 on diagnostic accuracy, the median diagnostic reasoning score was 76% for the GPT-4 group and 74% for the conventional resources group. GPT-4 alone scored 89%

50 physicians (26 attendings, 24 residents) participated, with an average of 5.2 cases completed per participant. The median diagnostic reasoning score per case was 76.3 percent (IQR 65.8 to 86.8) for the GPT-4 group and 73.7 percent (IQR 63.2 to 84.2) for the conventional resources group, with an adjusted difference of 1.6 percentage points (95% CI -4.4 to 7.6; p=0.60). GPT-4 alone scored 15.5 percentage points (95% CI 1.5 to 29, p=0.03) higher than the conventional resources group. The availability of GPT-4 to physicians as a diagnostic aid did not significantly improve clinical reasoning compared to conventional resources, although it may improve components of clinical reasoning such as efficiency. GPT-4 alone demonstrated higher performance than both physician groups, suggesting opportunities for further improvement in physician-AI collaboration in clinical practice.

Takeaways by Macro Roundup^® AI

Physicians given GPT-4 scored a median 76.3% on diagnostic reasoning per case versus 73.7% for those using conventional resources, an adjusted difference of 1.6 percentage points (95% CI -4.4 to 7.6; p=0.60).
GPT-4 alone scored 15.5 percentage points higher than the conventional resources physician group (95% CI 1.5 to 29, p=0.03) in a randomized clinical vignette study of 50 physicians, 26 attendings and 24 residents.
Availability of GPT-4 as a diagnostic aid did not significantly improve physicians' clinical reasoning over conventional resources, though it may improve components such as efficiency, suggesting opportunities for better physician-AI collaboration.

Ancient DNA Reveals Pervasive Directional Selection Across West Eurasia

Ali Akbari, Annabel Perry, Alison Barton, Mohammadreza Kariminejad, et al. Nature

Date Posted:: April 16, 2026
Is Database:: Database
Is Important:: Important

Ancient DNA from 15,836 West Eurasians reveals that natural selection accelerated dramatically in the past 10,000 years, following the agricultural revolution. The strongest selection drove improved immune function and lighter skin pigmentation.

We present a method for detecting directional selection in ancient DNA time-series data that tests for consistent trends in allele frequency change over time, and apply it to 15,836 West Eurasians (10,016 with new data). We estimate selection coefficients at 9.7 million variants, enabling study of how Darwinian forces couple to allelic effects and shape the genetic architecture of complex traits. We focused on 12 traits of particular interest with significant signals from all three tests (Figure 4). One of the strongest signals is an increase over time in the PGS for light skin pigmentation. Type 2 diabetes risk factors give compelling signals of negative selection. We detected negative polygenic selection against alleles associated today with psychoses such as bipolar disorder and schizophrenia. We finally observed signals of selection for combinations of alleles that today are associated with three correlated behavioural traits: scores on intelligence tests, household income and years of schooling. An important caveat is [that] these effects were measured in industrialized societies, and it remains unclear how these relate to phenotypes that were adaptive in the past.

Takeaways by Macro Roundup^® AI

Applying a new test for directional selection to ancient DNA from 15,836 West Eurasians, 10,016 with newly reported data, the authors estimate selection coefficients at 9.7 million variants to study how selection shapes the genetic architecture of complex traits.
Among 12 traits with significant signals from all three tests, one of the strongest is an increase over time in the polygenic score for light skin pigmentation, alongside negative selection on type 2 diabetes risk factors and on alleles associated today with bipolar disorder and schizophrenia.
The authors observed signals of selection on combinations of alleles associated today with intelligence test scores, household income, and years of schooling, while cautioning that these effects were measured in industrialized societies and their relation to past adaptive phenotypes remains unclear.

Self-Selection and the Diminishing Returns of Research

Lorenz Ekerdt and Kai-Jie Wu Working Paper

Date Posted:: December 9, 2024
Is Database:: Database

Ekerdt and Wu argue that the diminishing returns to research since the 1960s is a result of the 3X increase in the share of the labor force employed in research, which resulted in a transitional decline in the “average ability among researchers.”

We argue that a substantial portion of the declining productivity of research is the product of a transitional composition effect instead of a permanent phenomenon. We show that the share of the labor force employed in research has increased 3-fold since the 1960s. If workers are sorted into sectors according to ability, this rapid expansion cannot have been achieved without changing the average ability among researchers. If research is positively selected on ability, i.e., workers with a comparative advantage in research also tend to have an absolute advantage in research, the direction of this change is unambiguously negative. This source of diminishing returns is transitional because it is expected to fade away when the share of workers employed in research ceases to rise. Our results suggest that the average ability of researchers has fallen substantially. We find that separating transitional diminishing returns from permanent ones nearly doubles the long-run growth rate of per capita income predicted by a broad class of growth models.

Takeaways by Macro Roundup^® AI

The authors show the share of the labor force employed in research has risen 3-fold since the 1960s, an expansion they argue could not occur without lowering researchers' average ability if workers sort into sectors by ability.
The authors argue much of research's declining productivity is a transitional composition effect that fades once the research employment share stops rising, not a permanent phenomenon, and find average researcher ability has fallen substantially.
Separating transitional from permanent diminishing returns nearly doubles the long-run growth rate of per capita income predicted by a broad class of growth models, according to the authors.

The Next Battle in Higher Ed May Strike at Its Soul: Scholarship

Anemona Hartocollis The New York Times

Date Posted:: January 16, 2024
Is Database:: Database

Over 10,000 research papers were retracted in 2023 globally according to @Nature, up from 400 in 2010. The retractions are due to both increased scrutiny but also the rise of “paper writing mills” or low-quality journals.

A cottage industry of checking research papers sprung up in the last two decades, including Retraction Watch, the Center for Open Science, and Data Colada, a blog dedicated to unmasking research based on bad data. The number of retracted research papers has grown dramatically over time, to more than 10,000 retractions internationally in 2023, an annual record, according to the journal Nature, up from about 400 papers in 2010, when Retraction Watch began its work. This may be in part because the scrutiny has intensified, said Ivan Oransky, co-founder of Retraction Watch. Nature also blamed the rise of paper-writing mills. “What’s different this time is the levels at which this seems to be striking — Harvard and Stanford,” Dr. Oransky said. “These are cataclysmic events.”

Takeaways by Macro Roundup^® AI

Retracted research papers exceeded 10,000 internationally in 2023, an annual record, up from about 400 in 2010, according to the journal Nature.
Nature attributed part of the rise in retractions to paper-writing mills, while Retraction Watch co-founder Ivan Oransky said intensified scrutiny may also play a part.
A cottage industry of research checking has emerged over two decades, including Retraction Watch, the Center for Open Science, and Data Colada, with Oransky saying cases now strike Harvard and Stanford.

Florida Ocean Temperatures At ‘Downright Shocking’ Levels

Dan Stillman Washington Post

Date Posted:: July 11, 2023
Is Database:: Database

Coastal waters in Florida are currently between 92 and 96 degrees vs. typical averages in the upper 80s. About 40% of the world’s oceans are facing a marine heat wave according to @NOAA.

Much of Florida is seeing its warmest year on record, with temperatures running 3 to 5 degrees above normal. While some locations have been setting records since the beginning of the year, the hottest weather has come with an intense heat dome cooking the Sunshine State in recent weeks. That heat dome has made coastal waters extremely warm, including “downright shocking” temperatures of 92 to 96 degrees in the Florida Keys, meteorologist and journalist Bob Henson said Sunday in a tweet. “That’s boiling for them! More typically it would be in the upper 80s,” tweeted Jeff Berardelli, chief meteorologist and climate specialist at WFLA-TV in Tampa. The hot waters around Florida are connected to record-breaking ocean heat worldwide. About 40 percent of the world’s oceans are facing a marine heat wave, NOAA reported. That is the highest percentage on record, and it could reach 50 percent by September.

Takeaways by Macro Roundup^® AI

Water temperatures in the Florida Keys have reached 92 to 96 degrees, which meteorologist Bob Henson called "downright shocking"; WFLA-TV chief meteorologist Jeff Berardelli said such waters are more typically in the upper 80s.
Much of Florida is seeing its warmest year on record, with temperatures running 3 to 5 degrees above normal and an intense heat dome bringing the hottest weather in recent weeks.
NOAA reported that about 40 percent of the world's oceans face a marine heat wave, the highest percentage on record, and that share could reach 50 percent by September.

Earth Keeps Breaking Temperature Records Due to Global Warming

Will Mathis and Aaron Clark Bloomberg

Date Posted:: July 5, 2023
Is Database:: Database

The world’s global mean temperature reached a record 63°F on July 4th, topping a previous record of 62°F set in 2016.

The average worldwide temperature reached 17C (63F) on Monday, just above the previous record of 16.9C in August 2016, according to data from the National Centers for Environmental Prediction. The threshold only lasted a day. On Tuesday, the average temperature hit 17.2C.

Takeaways by Macro Roundup^® AI

The average worldwide temperature reached 17C (63F) on Monday, just above the previous record of 16.9C set in August 2016, according to data from the National Centers for Environmental Prediction.
The 17C mark held for only a day, as the global average temperature reached 17.2C on Tuesday.

Nonreplicable publications are cited more than replicable ones

Marta Serra-Garcia Science

Date Posted:: June 15, 2021
Is Database:: Database

Research in @ScienceAdvances finds papers that fail to replicate receive more citations than those that do replicate, even after publication of replication failures.

A study in Science Advances reveals that papers in top psychology, economics, and general interest journals that fail to replicate receive more citations than those that do replicate. This trend persists even after the publication of replication failures, with only 12% of subsequent citations acknowledging these failures. The quality of citations for nonreplicable papers is comparable to replicable ones, as measured by the impact factor of citing journals. Experts can predict which papers will replicate, yet nonreplicable papers are often published due to a trade-off between the perceived interest of results and reproducibility standards. This suggests a systemic issue in academic publishing where the allure of novel findings outweighs the importance of scientific rigor, potentially skewing economic and policy decisions based on unreliable data.

Takeaways by Macro Roundup^® AI

Papers in top psychology, economics, and general interest journals that fail to replicate receive more citations than those that do replicate, according to a study in Science Advances.
Only 12% of citations to nonreplicable papers published after replication failures acknowledge those failures, and the impact factor of citing journals is comparable for nonreplicable and replicable papers.
The Science Advances study reports that experts can predict which papers will replicate, and attributes publication of nonreplicable papers to a trade-off between the perceived interest of results and reproducibility standards.

New paper from Science Advances highlights the replication problem in science, “….We use publicly available data to show that published papers in top psychology, economics, and general interest journals that fail to replicate are cited more than those that replicate. This difference in citation does not change after the publication of the failure to replicate. Only 12% of post replication citations of nonreplicable findings acknowledge the replication failure. Existing evidence also shows that experts predict well which papers will be replicated. Given this prediction, why are nonreplicable papers accepted for publication in the first place? A possible answer is that the review team faces a trade-off. When the results are more “interesting,” they apply lower standards regarding their reproducibility….”

Core result, “…Our main finding is that papers that fail to replicate in (5-7) are cited more than those that are replicable. We find no significant change in citation trends, even after the publication of the failed replication. Notably, only a minority of publications after the failed replications were published acknowledge the failure. The “quality” of citations of papers that failed to replicate is similar to that of papers that were replicated: We do not find a difference in how often the citations of nonreplicable publications are cited by others or in the impact factor of the journals in which citations are published…”

The evidence, "...Figure 1 shows the distribution of total citation counts by the end of 2019 of the papers included in the replication projects, separately depending on replicability for Nature/Science, economics journals, and psychology journals. Replicability is measured according to the criterion that the replication project featured a P value of 0.05 or lower in a two-sided test, with an effect in the same direction as the original test….”

Nonreplicable publications are cited more than replicable ones: Extended Excerpt Image 1

Marta Serra-Garcia and Uri Gneezy, "Nonreplicable publications are cited more than replicable ones,"Science Advances, May 21, 2021, https://advances.sciencemag.org/content/7/21/eabd1705

In a trial with 50 physicians to test the impact of GPT-4 on diagnostic accuracy, the median diagnostic reasoning score was 76% for the GPT-4 group and 74% for the conventional resources group. GPT-4 alone scored 89%

Does giving doctors access to an AI model improve diagnostic reasoning?

Takeaways by Macro Roundup® AI

Related Articles:

Ancient DNA from 15,836 West Eurasians reveals that natural selection accelerated dramatically in the past 10,000 years, following the agricultural revolution. The strongest selection drove improved immune function and lighter skin pigmentation.

Has human genetic selection continued to shape traits across West Eurasia?

Takeaways by Macro Roundup® AI

Related Articles:

Ekerdt and Wu argue that the diminishing returns to research since the 1960s is a result of the 3X increase in the share of the labor force employed in research, which resulted in a transitional decline in the “average ability among researchers.”

Does expanding the research workforce explain falling research productivity?

Takeaways by Macro Roundup® AI

Related Articles:

Over 10,000 research papers were retracted in 2023 globally according to @Nature, up from 400 in 2010. The retractions are due to both increased scrutiny but also the rise of “paper writing mills” or low-quality journals.

Are retractions of research papers rising sharply?

Takeaways by Macro Roundup® AI

Related Articles:

Coastal waters in Florida are currently between 92 and 96 degrees vs. typical averages in the upper 80s. About 40% of the world’s oceans are facing a marine heat wave according to @NOAA.

How warm have Florida's coastal waters and oceans worldwide become?

Takeaways by Macro Roundup® AI

Related Articles:

The world’s global mean temperature reached a record 63°F on July 4th, topping a previous record of 62°F set in 2016.

Are global average temperatures setting new record highs?

Takeaways by Macro Roundup® AI

Related Articles:

Research in @ScienceAdvances finds papers that fail to replicate receive more citations than those that do replicate, even after publication of replication failures.

Do papers that fail to replicate receive more citations?

Takeaways by Macro Roundup® AI

Takeaways by Macro Roundup^® AI

Takeaways by Macro Roundup^® AI

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Takeaways by Macro Roundup^® AI

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