Private and Social Returns to RD: Drug Development and Demographics
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Intangible investment is increasingly focused on consumer products with limited productivity spillovers, particularly in the pharmaceutical sector.
Efraim Benmelech, Janice Eberly, Joshua Krieger and Dimitris Papanikolaou, "Private and Social Returns to R&D: Drug Development and Demographics," National Bureau Of Economic Research, January 2021, https://www.nber.org/papers/w28355



Ed Comment:“Nothing more to add!”
Great new NBER using evidence from the pharmaceutical sector (which parallels your story about your friend's biotech firm you invested in that was trying to extend the life of patients receiving advanced chemotherapy) productivity spillovers from pharmaceutical research are limited as the increased life expectancy/quality of life among the elderly increases social welfare but doesn't show up in TFP.
Obviously that relationship likely wouldn’t hold in terms of Covid related investment but they argue this trend is likely true across investment in intangible capital and is contributing to slower productivity growth.
Core argument, “…a significant share of this increased intangible investment is geared towards medical R&D targeting older patients. To the extent that these patients are no longer in the labor force, their improved health and well-being would be welfare-enhancing but not directly productivity-improving…”
They walk you though it here, “….First,we show that pharmaceutical firms account for an increasing share of the total R&D spending in the economy. In the 1970s, U.S. pharmaceutical firms accounted for less than 3% of the overall R&D spending in the economy. Today, that share has risen to approximately 10%, and their share among manufacturing firms has risen from 8% to 35%.Second, we show that much of this increased spending is geared towards developing drug candidates targeting ailments typically afflicting older patients. Using detailed data on firms’ drug development pipelines,we show that a significant share of drug candidates under development are treating diseases that disproportionately affect patients that have exited the labor force (over 65 years old)....We find that the share of expenditures allocated to treating diseases common in the over-65 year group has increased by more than 50% since 2000.Though much of our analysis is focusing on the post-2000 period, many of the trends we document are also present in the pre-2000 sample…Our estimates suggest that about a third of total R&D spending by pharmaceutical firms is geared towards those aged 65 and over. While prolonging life expectancy and improving quality of life, these investments in R&D have little effect on measured productivity and output growth.Male life expectancy at birth in the U.S. increased from 70 years in 1980 to 76.3 years in 2018. However, the effective retirement age for men has been hovering around 66 since 1980 and has risen only slightly to 67.9 by 2018, while the statutory retirement age increased from 65 to 66. Absent a significant change in retirement patterns, it is unlikely that R&D spending targeting seniors will directly enhance the labor force and hence output growth….”